The Best Medicine For Anxiety Disorders SSRIs (selective serotonin reuptake inhibitors) and SNRIs like citalopram (Celexa), escitalopram (Lexapro) and fluoxetine (Prozac) duloxetine (Cymbalta) and venlafaxine (Effexor XR) are considered to be the first-line treatment for anxiety disorders. Psychotherapy and exercise are also crucial for people suffering from anxiety. Antihistamines such